| Date | Home | Away | Result |
|---|---|---|---|
| 12/18/25 2:00 PM | FC Lausanne-Sport | Fiorentina | --- |
| 12/18/25 2:00 PM | AZ Alkmaar | Jagiellonia Bialystok | --- |
| 12/18/25 2:00 PM | Schachtjor Donezk | HNK Rijeka | --- |
| 12/18/25 2:00 PM | SK Slovan Bratislava | BK Häcken | --- |
| 12/18/25 2:00 PM | Legia Warschau | Lincoln Red Imps FC | --- |
| 12/18/25 2:00 PM | Sparta Prag | FC Aberdeen | --- |
| 12/18/25 2:00 PM | Dynamo Kiew | FC Noah | --- |
| 12/18/25 2:00 PM | Crystal Palace | Kuopion PS | --- |
| 12/18/25 2:00 PM | Rayo Vallecano | KF Drita Gjilan | --- |
| 12/18/25 2:00 PM | Shamrock Rovers | Hamrun Spartans | --- |
| 12/18/25 2:00 PM | Omonia Nicosia | KS Rakow Czestochowa | --- |
| 12/18/25 2:00 PM | FSV Mainz 05 | Samsunspor | --- |
| 12/18/25 2:00 PM | Racing Club Strasbourg | Breidablik Kopavogur | --- |
| 12/18/25 2:00 PM | NK Celje | FC Shelbourne | --- |
| 12/18/25 2:00 PM | HŠK Zrinjski Mostar | SK Rapid Wien | --- |
| 12/18/25 2:00 PM | AEK Athens | Universitatea Craiova | --- |
| 12/18/25 2:00 PM | Sigma Olomouc | Lech Poznan | --- |
| 12/18/25 2:00 PM | AEK Larnaka | KF Shkendija | --- |